MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression and play critical roles in cancer biology, cardiovascular disorders, neurological diseases, and immune responses. With the advancement of Next-Generation Sequencing (NGS), researchers in India can now identify both known and novel miRNAs with high sensitivity and accuracy. Understanding the difference between known and novel miRNA discovery is essential for effective genomics and transcriptomics research.
What is Known miRNA Identification?
Known miRNA identification involves detecting previously characterized miRNAs that are already documented in public databases such as miRBase. During NGS data analysis, small RNA reads are aligned to reference genomes and compared against curated miRNA databases.
This approach helps in:
Quantifying expression levels of established miRNAs
Performing differential expression analysis
Identifying disease-associated biomarkers
Supporting drug target validation
Known miRNA profiling is especially valuable in clinical research and biomarker discovery studies.
What is Novel miRNA Discovery?
Novel miRNA discovery focuses on identifying previously unreported miRNA sequences from NGS datasets. This requires advanced computational analysis, including:
Prediction of hairpin precursor structures
Secondary structure stability assessment
Read distribution pattern evaluation
Filtering false positives
Novel miRNA discovery expands the understanding of gene regulation and can uncover new therapeutic targets. In India’s growing precision medicine and RNA therapeutics sector, identifying novel regulatory RNAs is becoming increasingly important.
Importance for Indian Genomics Research
India is rapidly advancing in genomics, RNA-Seq analysis, and personalized medicine. Combining known and novel miRNA discovery provides:
Comprehensive transcriptome insights
Better understanding of disease mechanisms
Identification of new biomarkers
Stronger foundation for RNA-based drug development
Accurate computational pipelines are crucial to ensure reliable and reproducible results.
Why Choose BioNome
Recognized as the Best Bioinformatics Service Provider in Bangalore (Karnataka), BioNome offers affordable bioinformatics services for:
miRNA and siRNA identification
Small RNA-Seq analysis
Differential expression studies
Target gene prediction and pathway enrichment
End-to-end NGS data analysis
Our experienced team ensures high-quality data processing, precise analysis, and detailed reporting tailored to research needs.
Contact BioNome
📞 Phone: +91 8668470445
📧 Email: info@bionome.in
Advance your genomics research in India with expert Known and Novel miRNA Discovery services from BioNome, delivering accurate, affordable, and insight-driven NGS data analysis solutions.