Core Genome Analysis is a powerful approach in microbial genomics, enabling researchers to study conserved genes shared across all strains of a species. In Bangalore’s rapidly growing biotechnology and genomics sector, this method plays a crucial role in outbreak investigation, antibiotic resistance research, vaccine development, and evolutionary studies. At BioNome, we follow a structured and scientifically validated workflow to deliver accurate and research-ready results.
Recognized as the Best Bioinformatics Service Provider in Hennur (Karnataka), BioNome offers affordable bioinformatics services tailored to academic institutions, hospitals, pharmaceutical companies, and biotech startups.
Step 1: Data Collection & Quality Control
The workflow begins with collecting whole-genome sequencing (WGS) data in FASTQ format. Our team performs:
Quality assessment of raw reads
Adapter trimming and filtering
Removal of low-quality sequences
Contamination screening
Ensuring high-quality input data is critical for reliable downstream analysis.
Step 2: Genome Assembly & Annotation
High-quality reads are assembled into draft or complete genomes using optimized assembly tools. The assembled genomes are then annotated to identify genes, coding sequences, and functional elements. Accurate annotation is essential for identifying conserved core genes.
Step 3: Core Genome Identification
Using advanced comparative genomics pipelines, we:
Cluster orthologous genes across multiple strains
Identify genes common to all isolates (core genome)
Differentiate accessory and unique genes
Generate core gene alignment datasets
This step forms the foundation for phylogenetic and evolutionary analysis.
Step 4: Phylogenetic & SNP Analysis
We perform high-resolution SNP analysis within core genes to:
Construct phylogenetic trees
Track transmission patterns
Identify outbreak clusters
Study evolutionary relationships
This provides actionable insights for epidemiological and research applications.
Step 5: Reporting & Interpretation
BioNome delivers comprehensive reports including gene statistics, phylogenetic trees, SNP analysis summaries, and biological interpretation tailored to research objectives.
Why Choose BioNome?
BioNome combines technical expertise, high-performance computing, and validated genomic workflows to deliver accurate and reproducible results. Our affordable bioinformatics services in Bangalore ensure scalable solutions for complex comparative genomics projects.
Contact BioNome
📞 Phone: +91 8668470445
📧 Email: info@bionome.in
Partner with BioNome in Bangalore for expert Core Genome Analysis projects, delivering precise, affordable, and high-quality bioinformatics solutions for advanced genomic research.